📖 Clinical, Cosmetic and Investigational Dermatology📅 2026
AUTHORS
Luciana Leite Crivelin, Gabriela Tomasi-Batiston
ABSTRACT
Melasma is a challenging condition to treat, requiring multiple therapeutic approaches. Exosomes have been used as regenerative therapies in diverse contexts, including dermatological disorders. A 35-year-old male patient with Fitzpatrick skin phototype II and a longstanding diagnosis of facial melasma, who had undergone multiple prior treatments — including topical agents and laser therapy — with little to no improvement was treated with three monthly sessions of robotic microneedling without radiofrequency on the melasma-affected areas, followed by the injection of preconditioned autologous platelet-rich plasma.
