Photo-Thermal boosted platelets release a higher amount of growth factors in a controlled and sustained way for a more physiological effect.
Photo-thermal conditioning of cells and platelets stimulates exosome production and release, which play a very important role in homeostasis, vascular integrity, immunoregulation, inflammatory regulation, and angiogenesis.
They also have a major impact on health and aging.
EXOSOMES and blue light
Blue light illumination improves therapeutic effect of exosomes.
Elevated levels of miRNAs and mRNAs due to blue light exposure increase proangiogenic capacities in MSCs and MSCs Exosomes.
Blue opsin photo-transduction is an invaluable tool for cell regenerative power enhancement.
EXOSOMES and temperature
The frequency of exosome-cell membrane fusion events increases at higher temperatures.
The kinetics of exosome release is faster at higher temperatures.
A portion of exosomes are free to diffuse away from fusion site, but some remain attached. This process is temperature dependent with fewer exosomes remaining attached at higher temperatures.