AUTHORS
Elena Sánchez-Vizcaíno Mengual, Laura Cordero, Hernán Pinto
ABSTRACT
This correspondence presents photothermal biomodulation (PTBM) as an emerging strategy to precondition platelet-rich plasma (PRP) before administration. By combining specific light wavelengths (red and blue) with controlled temperature modulation, PTBM aims to prime platelet behavior and downstream signaling in a standardized way, modulating growth factor release and the secretion of extracellular vesicles such as exosomes. In vitro evidence suggests fluence-dependent increases in exosome release, and early pilot and case-based reports across wound care, musculoskeletal repair, and other regenerative contexts describe favorable tolerability. The authors emphasize that these findings remain preliminary and hypothesis-generating: standardized protocols and well-designed randomized controlled trials are needed to define clinical relevance, optimal parameters, and long-term safety.
