Q&A
MCT is a new procedure in regenerative medicine. Whether you are using PRP or other autologous preparates, it allows the delivery of more effective treatments.
What is MCT and why should I have it in my practice?
MCT System is a pioneering technology that enhances regenerative medical treatments through the application of electromagnetic and thermal energy. At the core of the system lies the MCT Kit®, a patented medical-grade cassette precisely designed for photothermal conditioning; and the MCT Unit®, a device equipped to generate and apply the photothermal stimulus.
Which is the innovative concept behind MCT Technology?
The synergy between the cutting-edge features of the MCT Kit® and the versatile functionality of the MCT Unit® forms the foundation of a revolutionary innovation conceived to elevate the regenerative potential of PRP and cell-based therapies, while stimulating the production and deliverance of autologous exosomes.
Which unique features define the MCT Unit®?
The MCT Unit® emits light across a versatile wavelength spectrum (467 nm to 850 nm): blue light (467 nm), green light (530 nm), yellow light (591 nm), red light (620 nm), and infrared light (850 nm). Additionally, it is equipped to stimulate biological materials within a temperature range of 4ºC to 45ºC.
What key properties make the MCT Kit® a game-changer?
The MCT Kit® is a patented medical-grade cassette serving as the receptacle for patient material, uniquely crafted to fit in the MCT Unit®. It has two syringe docking sites (standard and Luer Lock® compatible) to insert and extract autologous material.
What effects does MCT photobiomodulation elicit?
Direct exposure of cells to light profoundly affects chromophores, including cytochrome C oxidase and opsins. These light-responsive receptors activate second messengers (ROS, Ca2+, ATP, cAMP, NO), modulating cell signaling pathways.
What outcomes does MCT thermal biomodulation achieve?
It is well known that low temperatures (4ºC) prime platelet activation and trigger the release of growth factors (VEGF, EGF, and bFGF) from α-granules. Additionally, temperature directly influences exosome secretion kinetics, with increased exosome release at higher temperatures (37ºC).
What treatments can I enhance with MCT Technology and to what extent?
All autologous materials can be enhanced with the MCT System. That is, basically, PRP, SVF, and every other regenerative medicine preparate. Therapy enhancement translates, for instance, into considerably fewer sessions and stunning clinical results. Safe, effective, evidence-proof photothermal boosting treatments are here to stay.
When are MCT treatment effects noticeable?
There is a “flash” effect that can be seen almost immediately and an antiaging effect whose results can be seen in less than a month but can be enhanced with time due to the regenerative power of exosomes.
Using the MCT System
Which are the MCT presets and what are they for?
There are 3 individual MCT presets (PRP, Cells, and Exosomes) each tailored to achieve specific therapeutic goals. PRP preset improves platelet performance to achieve better clinical outcomes, Cells preset stimulates cell metabolism for superior cellular-based therapy results, and Exosomes preset induces the shedding of exosomes, boosting the regenerative power of any product.
What kind of sample material is advised for each MCT preset?
PRP preset is recommended for plasma-derived products, such as PRP (platelet-rich plasma) or PPP (platelet-poor plasma). Cells preset is versatile and can be employed for various cell types, including serum, biopsies, stromal vascular fraction, stem cells, as well as other cell types. Exosomes preset is suitable for any biologic liquid containing living cells or platelets.
How should the patient sample be for an MCT Treatment?
For MCT Technology to exert its therapeutic effects, autologous material must be liquid and contain living cells or platelets.
Which is the standard MCT protocol?
The MCT protocol involves 3 key steps. First, procuring the autologous material from the patient. Second, inserting the patient’s material into the MCT Kit®. Third, setting up the MCT Unit® with the loaded MCT Kit®, running the preferred MCT preset, extracting the MCT material once the session is over, and administering it to the patient.
Can I combine multiple MCT presets to treat the same patient?
Yes. There are 3 different MCT presets (PRP, Cells, and Exosomes presets) which can be used individually. However, for a superior outcome we strongly recommend splitting the patient material and combining PRP or Cells presets with Exosomes preset.
What is a combined MCT treatment?
A combined MCT treatment merges PRP or Cells presets with the Exosomes preset for enhanced therapeutic results. Patient’s material is split in two halves of equal volume. The first half is used for either PRP or Cells presets to obtain MCT Plasma or MCT Cells respectively, while the second half is used to run Exosomes preset and generate MCT Exosomes. This way the patient receives MCT Plasma or MCT Cells, as well as MCT Exosomes.
Which is the recommended starting volume of patient material?
The MCT Kit® allows a maximum of 10 mL. While 10 mL is enough for individual MCT treatments, we recommend an initial volume of 20 mL for combined MCT treatments. These 20 mL can be divided into two 10 mL halves for individual presets.
How long does a session of a combined MCT treatment last?
PRP or Cells presets are first run on the MCT Unit® to obtain MCT Plasma or MCT Cells. While the patient receives MCT Plasma or MCT Cells, Exosomes preset can be started to generate MCT Exosomes. By performing these steps simultaneously, the duration of the session can be reduced up to 25-30 minutes.
Which is the recommended administration timeline for an MCT treatment?
We recommend scheduling treatment sessions with a 3-week interval and maintaining a span of 4-6 months between subsequent maintenance sessions. While this timeline serves as a general guideline, it is essential to tailor it to the specific needs of each individual patient if necessary.
MCT Exosomes & MCT Plasma
What are exosomes and which role they play in cell biology?
Exosomes, sized 40 to 160 nm, are a subtype of extracellular vesicles (EVs) released via endosomal pathways. They carry proteins (cytoskeletal, enzyme, heatshock, nuclear, extracellular matrix), nucleic acids (DNA, mRNA, miRNA), metabolites, amino acids, and lipids. As crucial mediators of intercellular communication, exosomes impact gene regulation, cell survival, proliferation, angiogenesis, wound healing, and metabolic reprogramming.
In what ways do exosomes shape skin dynamics?
Exosomes originating from keratinocytes, fibroblasts, stem cells, and diverse skin cells play a pivotal role in a range of critical functions, spanning from the self-renewal of the epidermis to skin regeneration, hair follicle stem cell proliferation and differentiation, and the modulation of immunological processes crucial for skin homeostasis.
How do exosomes boost dermatological and cutaneous medical aesthetic therapies?
Exosomes, with their unique ability to transfer biological information and promote tissue repair, emerge as a promising strategy for addressing diverse skin disorders. From wound healing to pigmentation regulation, skin rejuvenation, hair loss recovery, and scar remodeling, exosomes hold promise in diverse therapeutic applications.
What are the main distinctions between autologous and heterologous (allogeneic and xenogeneic) exosomes?
The main distinctive factor among autologous, allogeneic, and xenogeneic exosomes lies in their source. Autologous exosomes originate from cells of the same individual, allogeneic exosomes derive from cells of a different individual of the same species, and xenogeneic exosomes come from cells of a different species.
How do differences between autologous and heterologous exosomes translate into their clinical application and effects?
Autologous exosomes benefit from immune privilege, while heterologous exosomes are prone to triggering an immune response in the patient. The resulting immunogenic response contributes to the short-lived nature of heterologous exosomes, limiting their efficacy and therapeutic potential. Safety concerns also arise from the potential risk of cross- or intra-species contamination associated with the use of heterologous exosomes. All these factors position autologous exosomes as a valid medicinal therapeutic option, while heterologous exosomes are primarily confined to cosmetic applications.
What makes MCT Exosomes unique compared to other exosome-related products?
Unlike conventional methods that merely isolate or concentrate exosomes in cosmetic products, our technology goes beyond; it actively stimulates the production and release of naïve autologous exosomes from cells and platelets. This unique approach sets MCT technology apart from other exosome products in the market, positioning MCT Exosomes as a secure, efficient, potent, and reliable therapeutic option.
What differentiates MCT Plasma to standard PRP?
MCT technology elevates standard PRP to MCT Plasma, enhancing growth factor release, refining platelet activation, reducing proinflammatory cytokines, optimizing pH balance, decreasing plasma density for a more comfortable injection, and stimulating platelet metabolism via ATP synthesis.
How can I suggest MCT Plasma to my patients?
The best approach is to let them know that there is a new, enhanced regenerative product that is much stronger than standard PRP. It is a new generation top tech treatment that is called MCT Plasma and will lead them to better results in fewer sessions.