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Q&A

MCT is a new procedure in regenerative medicine. Whether you are using PRP or other autologous preparates, it allows the delivery of more effective treatments.

MCT System general Qs

What is MCT and why should I have it in my practice?

MCT System is a pioneering technology that enhances regenerative medical treatments through the application of electromagnetic and thermal energy.  At the core of the system lies the MCT Kit®, a patented medical-grade cassette precisely designed for photothermal conditioning; and the MCT Unit®, a device equipped to generate and apply the photothermal stimulus.

Which is the innovative concept behind MCT Technology?

The synergy between the cutting-edge features of the MCT Kit® and the versatile functionality of the MCT Unit® forms the foundation of a revolutionary innovation conceived to elevate the regenerative potential of PRP and cell-based therapies, while stimulating the production and deliverance of autologous exosomes.

Which unique features define the MCT Unit®?

The MCT Unit® emits light across a versatile wavelength spectrum (467 nm to 850 nm): blue light (467 nm), green light (530 nm), yellow light (591 nm), red light (620 nm), and infrared light (850 nm). Additionally, it is equipped to stimulate biological materials within a temperature range of 4ºC to 45ºC.

What key properties make the MCT Kit® a game-changer?

The MCT Kit® is a patented medical-grade cassette serving as the receptacle for patient material, uniquely crafted to fit in the MCT Unit®. It has two syringe docking sites (standard and Luer Lock® compatible) to insert and extract autologous material.

What effects does MCT photobiomodulation elicit?

Direct exposure of cells to light profoundly affects chromophores, including cytochrome C oxidase and opsins. These light-responsive receptors activate second messengers (ROS, Ca2+, ATP, cAMP, NO), modulating cell signaling pathways.

What outcomes does MCT thermal biomodulation achieve?

It is well known that low temperatures (4ºC) prime platelet activation and trigger the release of growth factors (VEGF, EGF, and bFGF) from α-granules. Additionally, temperature directly influences exosome secretion kinetics, with increased exosome release at higher temperatures (37ºC).

What treatments can I enhance with MCT Technology and to what extent?

All autologous materials can be enhanced with the MCT System. That is, basically, PRP, SVF, and every other regenerative medicine preparate. Therapy enhancement translates, for instance, into considerably fewer sessions and stunning clinical results. Safe, effective, evidence-proof photothermal boosting treatments are here to stay.

When are MCT treatment effects noticeable?

There is a “flash” effect that can be seen almost immediately and an antiaging effect whose results can be seen in less than a month but can be enhanced with time due to the regenerative power of exosomes.

Using the MCT System

Which are the MCT presets and what are they for?

There are 3 individual MCT presets (PRP, Cells, and Exosomes) each tailored to achieve specific therapeutic goals. PRP preset improves platelet performance to achieve better clinical outcomes, Cells preset stimulates cell metabolism for superior cellular-based therapy results, and Exosomes preset induces the shedding of exosomes, boosting the regenerative power of any product.

What kind of sample material is advised for each MCT preset?

PRP preset is recommended for plasma-derived products, such as PRP (platelet-rich plasma) or PPP (platelet-poor plasma). Cells preset is versatile and can be used with: biopsies, stromal vascular fraction, stem cells, as well as other cell types. Exosomes preset is suitable for any autologous liquid containing living cells or platelets.

How should the patient sample be for an MCT Treatment?

For MCT Technology to exert its therapeutic effects, autologous material must be liquid and contain living cells or platelets.

Which is the standard MCT protocol?

The MCT protocol involves 3 key steps. First, procuring the autologous material from the patient. Second, inserting the patient’s material into the MCT Kit®. Third, setting up the MCT Unit® with the loaded MCT Kit®, running the preferred MCT preset, extracting the MCT material once the session is over, and administering it to the patient.

Can I combine multiple MCT presets to treat the same patient?

Yes. There are 3 different MCT presets (PRP, Cells, and Exosomes) which can be combined or used individually according to physician criteria.

What is a combined MCT treatment?

A combined MCT treatment merges PRP or Cells presets with the Exosomes preset for enhanced therapeutic results. Split any autologous sample in two halves. Use the first one with either PRP or Cells presets and the second with the exosomes preset.

Which is the starting volume for a treatment?

The MCT Kit® allows a maximum of 10 mL. While 10 mL is enough for individual MCT treatments, a higher volume will generally be needed for combined treatments.

How long does a session of a MCT treatment last?

Single preset treatments require 10 to 15 minutes. Combined preset treatments require 25 minutes.

Which is the recommended administration timeline for an MCT treatment?

Many physicians recommend a scheme of 3 sessions with a 3-week interval and maintaining a span of 4-6 months between subsequent maintenance sessions. While this timeline serves as a general guideline, every physician will tailor the procedure to the specific needs.

Exosomes & PRP

What are exosomes and which role they play in cell biology?

Exosomes, sized 40 to 160 nm, are a subtype of extracellular vesicles (EVs) released via endosomal pathways. They carry proteins (cytoskeletal, enzyme, heatshock, nuclear, extracellular matrix), nucleic acids (DNA, mRNA, miRNA), metabolites, amino acids, and lipids. As crucial mediators of intercellular communication, exosomes impact gene regulation, cell survival, proliferation, angiogenesis, wound healing, and metabolic reprogramming.

In what ways do exosomes shape skin dynamics?

Exosomes originating from keratinocytes, fibroblasts, stem cells, and diverse skin cells play a pivotal role in a range of critical functions, spanning from the self-renewal of the epidermis to skin regeneration, hair follicle stem cell proliferation and differentiation, and the modulation of immunological processes crucial for skin homeostasis.

How do exosomes boost dermatological and cutaneous medical aesthetic therapies?

Exosomes, with their unique ability to transfer biological information and promote tissue repair, emerge as a promising strategy for addressing diverse skin disorders. From wound healing to pigmentation regulation, skin rejuvenation, hair loss recovery, and scar remodeling, exosomes hold promise in diverse therapeutic applications.

What are the main distinctions between autologous and heterologous (allogeneic and xenogeneic) exosomes?

The main distinctive factor among autologous, allogeneic, and xenogeneic exosomes lies in their source. Autologous exosomes originate from cells of the same individual, allogeneic exosomes derive from cells of a different individual of the same species, and xenogeneic exosomes come from cells of a different species.

How do differences between autologous and heterologous exosomes translate into their clinical application and effects?

Autologous exosomes benefit from immune privilege, while heterologous exosomes are prone to triggering an immune response in the patient. The resulting immunogenic response contributes to the short-lived nature of heterologous exosomes, limiting their efficacy and therapeutic potential. Safety concerns also arise from the potential risk of cross- or intra-species contamination associated with the use of heterologous exosomes. All these factors position autologous exosomes as a valid medicinal therapeutic option, while heterologous exosomes are primarily confined to cosmetic applications.

What makes MCT System unique compared to other products?

Unlike conventional methods that merely isolate or concentrate exosomes in cosmetic products, our technology goes beyond; it actively stimulates the release of naïve exosomes from cells and platelets. This unique approach sets MCT technology apart from other products in the market, positioning us as the only secure, efficient, potent, and reliable therapeutic option.

What is the difference with a standard PRP?

MCT technology elevates standard PRP, enhancing growth factor release, refining platelet activation, reducing proinflammatory cytokines, optimizing pH balance, decreasing plasma density for a more comfortable injection, and stimulating platelet metabolism via ATP synthesis.